Dapsone: (Moderate) Coadministration of dapsone with nitrates may increase the risk of developing methemoglobinemia. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. Monitor Closely (1)nitroglycerin rectal, isosorbide dinitrate. Monitor Closely (1)crofelemer increases levels of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Carbinoxamine; Dextromethorphan; Pseudoephedrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Either increases effects of the other by pharmacodynamic synergism. Anginal pain may be induced when coronary insufficiency is present. Guaifenesin; Pseudoephedrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Benzalkonium Chloride; Benzocaine: (Moderate) Rare and sometimes fatal cases of methemoglobinemia have been reported with the use of topical or oromucosal benzocaine products. Either increases effects of the other by pharmacodynamic synergism. Nitric oxide activates the enzyme guanylate cyclase, thereby stimulating the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP). Isosorbide dinitrate is a white, crystalline compound, has a melting point of 70°C and has an optical rotation . It relaxes blood vessels, increasing the blood and oxygen supply to your heart. Safety and efficacy have not been established. Modify Therapy/Monitor Closely. Dosage adjustments may be necessary. Minor/Significance Unknown. Severe hypotension, particularly with upright posture, may occur with even small doses of isosorbide dinitrate in any group. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Serious - Use Alternative (1)voxelotor will increase the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. What does Isosorbide dinitrate look like? It may be advisable to monitor blood pressure. Increased risk of orthostatic hypotension. Geoffrey Hartzler-my hand is over my heart in hommage to your work. Carbetapentane; Diphenhydramine; Phenylephrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Syncope was reported in some patients. It will not help to stop an episode of chest pain. It will not help to stop an episode of chest pain. ISOSORBIDE DINITRATE. Monitor Closely (1)efavirenz will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)bosentan will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dexbrompheniramine; Pseudoephedrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. طلب البحث متطابق مع محتوى داخل الكتاب – صفحة ccxlviiISOSORBIDE DINITRATE CAPSULE, EXTENDED RELEASE; DILATRATE-SR + SCHWARZ PHARMA TABLET; ORAL ISORDIL AB AB AB AB ... AB + 20MG 10MG 20MG 20MG 20MG A075037 10MG A075037 20MG N019091 TABLET, EXTENDED RELEASE; ORAL ISOSORBIDE MONONITRATE AB ... Diphenhydramine; Phenylephrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. طلب البحث متطابق مع محتوى داخل الكتاب – صفحة xvii... Isoniazid Tablets (100 mg) 324 Isosorbide Dinitrate Tablets (5 mg) Indur 324 Isosorbide Dinitrate Tablets 324 Isosorbide Dinitrate Tablets (5 mg) 325 Isosorbide Dinitrate Tablets (10 mg) 325 Isovaleramide Sustained-Release Tablets ... Do not store in the bathroom. At oral doses 35 and 150 times the daily Maximum Recommended Human Dose (MRHD), isosorbide dinitrate has been shown to cause a dose related increase in embryotoxicity (increase in mummified pups) in rabbits. Either increases effects of the other by pharmacodynamic synergism. Rosiglitazone: (Major) The concomitant use of nitrates with rosiglitazone is not recommended. carbamazepine will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Risk of increased SBP, angina pectoris. Generic name: isosorbide dinitrate (EYE soe SOR bide dye NYE trate) Brand name: Dilatrate-SR, Isochron, Isordil, Sorbitrate, Isordil Titradose, ISDN, Isordil Tembids Dosage forms: oral capsule, extended release (40 mg); oral tablet (10 mg; 20 mg; 30 mg; 40 mg; 5 mg); oral tablet, extended release (40 mg); sublingual tablet (2.5 mg; 5 mg) Drug class: Antianginal agents Anginal pain may be induced when coronary insufficiency is present. High-dose isosorbide dinitrate at a dosage of 120 mg PO 4 times daily was administered to 24 patients with anginal attacks that did not respond to 10 mg PO 4 times daily. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Isosorbide dinitrate is a white, crystalline compound, has a melting point of 70°C and has an optical rotation . Avoid or Use Alternate Drug. Monitor Closely (1)stiripentol, isosorbide dinitrate. Anginal pain may be induced when coronary insufficiency is present. Avoid coadministration with other drugs that decrease pulse or blood pressure to mitigate risk of excessive bradycardia and hypotension. Monitor Closely (1)isosorbide dinitrate, arginine. Dextromethorphan; Diphenhydramine; Phenylephrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Isosorbide Dinitrate 10mg Tab Par Pharmaceuticals, an Endo Company. Epoprostenol: (Moderate) Concomitant use of nitrates with other antihypertensive agents can cause additive hypotensive effects. Use Caution/Monitor. Use Caution/Monitor. Diseases & Conditions, 2003 Anginal pain may be induced when coronary insufficiency is present. If methemoglobinemia occurs or is suspected, discontinue ropivacaine and any other oxidizing agents. commonly, these are generic drugs. طلب البحث متطابق مع محتوى داخل الكتاب – صفحة ccxxvi... 0.2MG/ML N010515 001 ISOSORBIDE DINITRATE CAPSULE, EXTENDED RELEASE;ORAL DILATRATE-SR + ACTIENT PHARMS 40MG N019790 001 Sep 02, 1988 TABLET;ORAL ISORDIL AB VALEANT BERMUDA 5MG N012093 007 Jul 29, 1988 AB 10MG N012093 002 Jul 29, ... The mechanisms responsible for nitrate tolerance are not fully understood; however, proposed mechanisms include neurohormonal counterregulatory mechanisms including activation of reflex vasoconstriction, intravascular volume expansion, desensitization of guanylate cyclase, depletion of sulfhydryl groups in vascular smooth muscle, a decrease in nitroglycerin biotransformation, or nitrate-mediated vascular superoxide production. Titrate dose at weekly intervals up to a target dose of 40 mg PO 3 times daily. Anginal pain may be induced when coronary insufficiency is present. rifampin will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. isosorbide dinitrate, bupivacaine implant. Monitor Closely (1)isosorbide dinitrate, captopril. Monitor Closely (1)etravirine will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Thank you!!! Modify Therapy/Monitor Closely. Carbinoxamine; Pseudoephedrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Use Caution/Monitor. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug include: drugs to treat erectile dysfunction-ED or pulmonary hypertension (such as sildenafil, tadalafil), certain drugs to treat migraine headaches (ergot alkaloids such as ergotamine), riociguat.Some products have ingredients that could worsen your heart failure. 3. Each drug may cause hypotension. Isosorbide dinitrate (ISDN) is 1,4:3,6-dianhydro-D-glucitol 2,5-dinitrate, an organic nitrate whose structural formula is . Monitor patients closely for signs and symptoms of methemoglobinemia if coadministration is necessary. For maintenance therapy, 10 to 40 mg, 2 or 3 times daily has been suggested. Isosorbide Dinitrate tablets 20mg are white to off-white, circular, flat bevelled-edge uncoated tablets Carbetapentane; Phenylephrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. voxelotor will increase the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Anginal pain may be induced when coronary insufficiency is present. Acetaminophen; Pseudoephedrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. 0 Ergoloid Mesylates: (Contraindicated) Ergot alkaloids are contraindicated in patients with hypertension, angina, or coronary artery disease; which are the primary patient populations for which nitroglycerin is utilized. Depending on the severity of symptoms, patients may respond to supportive care; more severe symptoms may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen. Use Caution/Monitor. Isosorbide dinitrate has an average rating of 3.4 out of 10 from a total of 6 ratings on Drugs.com. طلب البحث متطابق مع محتوى داخل الكتاب – صفحة 728Isosorbide Mononitrate PO (Adults): ISMO, Monoket—5–20 mg twice daily with the 2 doses given 7 hr apart. Imdur—30–60mg once daily; ... Availability Isosorbide Dinitrate (generic available) Tablets: 5 mg, 10 mg, 20 mg, 30 mg, 40 mg. Possible hypotension. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. Use Caution/Monitor. Monitor Closely (1)fedratinib will increase the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Ropivacaine: (Moderate) Coadministration of ropivacaine with oxidizing agents, such as nitrates, may increase the risk of developing methemoglobinemia. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)isosorbide dinitrate, bretylium. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternate therapies. If methemoglobinemia occurs or is suspected, discontinue prilocaine and any other oxidizing agents. blurred vision. Description: Isosorbide dinitrate, a nitro vasodilator, is a source of nitric oxide which stimulates cyclic guanosine 3',5'monophosphate (cGMP), thereby relaxing the vascular smooth muscles. elagolix decreases levels of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Anginal pain may be induced when coronary insufficiency is present. Brompheniramine; Hydrocodone; Pseudoephedrine: (Moderate) Sympathomimetics can antagonize the antianginal effects of nitrates, and can increase blood pressure and/or heart rate. Anginal pain may be induced when coronary insufficiency is present. The inactive ingredients in each tablet are lactose, cellulose, and magnesium stearate. Avoid or Use Alternate Drug. طلب البحث متطابق مع محتوى داخل الكتاب... 100s PERSANTINE ISOSORBIDE DINITRATE TABLETS , ORAL 10 mg 90s ISOSORBIDE DINITRATE TABLETS , ORAL 20 mg 90s ISOSORBIDE DINITRATE TABLETS , ORAL 20 mg 1000s ISORDIL ISOSORBIDE SOLUTION 220 ml ISOTRETINOIN CAPSULES 10 mg 100s ACCUTANE ... Monitor Closely (1)nafcillin will decrease the level or effect of isosorbide dinitrate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)isosorbide dinitrate increases effects of ergotamine by decreasing metabolism. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Anginal pain may be induced when coronary insufficiency is present. Talk to your doctor if you are using marijuana (cannabis).Before having surgery, tell your doctor or dentist that you are using this medication.Older adults may be more sensitive to the side effects of this medication, especially dizziness and lightheadedness, which could increase the risk of falls.During pregnancy, this medication should be used only when clearly needed.
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